LPL and hyperinsulinemic hypoglycemia, familial, 4: The first rAAV-based drug, Glybera (Alipogene Tiparvovec, AT), which was approved by the European Union, is an AAV1 vector drug that delivers DNA encoding functional lipoprotein lipase (LPL) to skeletal muscle for patients with LPL deficiency due to gene mutations (13), but it was taken off the market soon after its release because the price was unexpectedly high.