Nine CpG sites in the ACTB amplicon showed significantly higher methylation in CHD cases compared to controls (ACTB_CpG_2.3, ACTB_CpG_7.8, ACTB_CpG_9.10, ACTB_CpG_12, and ACTB_CpG_15.16, ORs per +10% methylation ranging from 1.19 to 1.45, p < 0.013, FDR-adjusted p-value < 0.019 for all by logistic regression model 2, Table 2). The gene discussed is ACTB; the disease is coronary artery disorder.