In the group ≥ 60 years old, the methylation patterns of ACTB were similar as in the younger group, and eight CpG sites showed significantly higher methylation in CHD cases than in controls (ACTB_CpG_2.3, ACTB_CpG_7.8, ACTB_CpG_9.10, and ACTB_CpG_15.16, ORs per +10% methylation ranging from 1.33 to 1.71, p < 0.020 for all by logistic regression model 2, Table 4B). The gene discussed is ACTB; the disease is coronary artery disorder.