We further investigated the association between these CHD subtypes and the blood-based methylation level of ACTB. The association between ACTB hypermethylation and CHD was mainly originated from the non-MI CHD cases, where nine CpG sites exhibited significantly higher methylation levels in the non-MI CHD cases than in the controls (ACTB_CpG_2.3, ACTB_CpG_7.8, ACTB_CpG_9.10, ACTB_CpG_15.16, and ACTB_CpG_17, ORs per +10% methylation ranging from 1.16 to 1.53, p < 0.035 for all by logistic regression model 2, Table 5A). The gene discussed is ACTB; the disease is coronary artery disorder.