The methylation levels of six CpG sites in the ACTB amplicon were higher in HF cases than that in controls [for ACTB_CpG_2.3, OR per +10% methylation (95% CI) = 1.39 (1.19–1.63), p = 3.10 × 10−5; for ACTB_CpG_7.8, OR per +10% methylation (95% CI) = 1.38 (1.18–1.62), p = 6.00 × 10−5; for ACTB_CpG_9.10, OR per +10% methylation (95% CI) = 1.46 (1.20–1.78), p = 1.52 × 10−4, logistic regression model 2, Table 6]. This evidence concerns the gene ACTB and hydrops fetalis.