The major findings of our study were (1) CTRP family members, as pro-inflammatory or anti-inflammatory adipokines, were independent predictors for ACS; (2) the association between CTRP family and ACS was not significantly affected by sex, age, DM, and dyslipidemia status; (3) increasing levels of CTRP1, CTRP2, CTRP12, and CTRP13 showed a linear trend with the risk of ACS; and (4) the serum levels of CTRP1, CTRP2, CTRP13, and CTRP15 showed a weak correlation with the severity of coronary artery stenosis. The gene discussed is C1QTNF2; the disease is metabolic syndrome.