MAX and neoplasm: Our current study uncovered the following novel findings: (1) miR-22 is hypermethylated and downregulated in CRC tissues; (2) miR-22 is a functional tumor suppressor in CRC, which can suppress EMT, migration, invasion, and glycolysis of CRC cells; (3) miR-22 directly targets MAX in CRC; and (4) miR-22 can prevent CRC progression by targeting MAX (Figure 11).