For instance, miR-22 can notably restrain CRC invasion and metastasis through NLRP3 [34], miR-214 can also prominently suppress CRC cell metastasis by targeting BCL9L to inhibit the Wnt pathway [35], and miR-22 also has a blocking effect on the process of CRC metastasis by negative regulation of SP1 [36]. Here, SP1 is linked to colorectal carcinoma.