METTL3 and ischemia reperfusion injury: For example, ischemia-reperfusion injury (IRI) and hypoxia/reoxygenation (H/R) cardiomyocytes in mice have been shown to downregulate METTL3, whilst the overexpression of METTL3 has been shown to mitigate the IRI and H/R-induced cells' death [15].