Enrichment analysis of experimentally validated targets of these four miRNAs revealed 112 statistically significant pathways enriched among the experimentally validated targets of these four miRNAs, including neurogenesis, response to cytokine, neurotrophin signaling, VEGF signaling, relaxin signaling, and cellular senescence pathways, which were implicated in MDD previously. Here, BDNF is linked to major depressive disorder.