NR3C1 and Anxiety: Indeed, in our previous study, we showed maternal methylation of the NR3C1 promoter region as negatively and significantly associated with parenting stress, which is a known marker of parent-child relationship disturbance and is predictive of both child internalizing (i.e., anxiety and depression) and externalizing problems (i.e., disruptive behavior disorder symptoms such as those of attention deficit hyperactivity, oppositional defiant and disruptive mood dysregulation disorder) (10, 18).