The goal of the present study involving mothers and children was to take our previous study one step further, by considering the relationship of maternal and child methylation of the NR3C1 promoter regions during an early developmental period sensitive to the caregiving environment that is adversely affected by maternal IPV-PTSD and its perturbation of psychobiological regulation of emotion and arousal. Here, NR3C1 is linked to post-traumatic stress disorder.