MAP2K6 and colorectal carcinoma: Interestingly, it has been found that miR-422a also regulates the expression of AKT1, MAPK1, MAPKK6, and other inflammatory-related factors in CRC, thereby affecting the proliferation and apoptosis of CRC cells (Li et al., 2018; Liang et al., 2021; Wei et al., 2017).