After the DSS-induced mice model establishment (Supplementary Figure S3), we examined the mRNA expression levels of CTLA4 and three strongly correlated mRNAs (FYN, ITK, and IGTB2) in the top 10 hub mRNAs (Figure 9A) and the lncRNA expression levels of myocardial infarction-associated transcript (MIAT) with qRT-PCR to verify the dataset’ reliability. The gene discussed is FYN; the disease is myocardial infarction.