Mutations in STPLC1 and SPTLC2 have been associated with hereditary sensory and autonomic neuropathy types IA and IC (HSAN1A and HSAN1C), respectively (Rotthier et al., 2010; Murphy et al., 2013; Oswald et al., 2015). Here, SPTLC2 is linked to neuropathy, hereditary sensory and autonomic, type 1A.