Another possible explanation is the increase of atypical sphingolipids, such as 1-deoxysphingolipids, which are synthesized by a noncanonical substrate alanine or glycine, instead of serine, catalyzed by serine palmitoyl transferase (SPT), and plays a neurotoxic role in the pathogenesis of neuropathy (Penno et al., 2010; Ferreira et al., 2018). This evidence concerns the gene AGXT and neuropathy.