P63, also known as tumor protein 63 (TP63) or transformation-related protein 63 (Trp63) or amplified in squamous cell carcinoma (AIS), is a member of the p53 transcription factor family and the corresponding p53/p63/p73 gene family that encodes p53, p63 and p73 proteins (Soares and Zhou, 2018; Fisher et al., 2020). Here, TP63 is linked to androgen insensitivity syndrome.