Unlike EGFR activation of phosphatidylinositol 3-kinase (PI3K) signaling in keratinocytes, EGFR activation of ΔNp63α is mediated by STAT3 in cancer, and these two pathways are potentially linked via the mammalian target of rapamycin (mTOR) as PI3K activation of mTOR results in mTOR-dependent activation of the STAT3/p63/Jagged pathway. This evidence concerns the gene STAT3 and cancer.