Moreover, the lncRNA NR2F1-AS1 was reported to be associated with the progression of various types of tumor, for instance by activating the IGF-1/IGF-1R/ERK pathway to promote breast cancer angiogenesis, inducing breast cancer lung metastasis dormancy by regulating NR2F1 and deltaNp63 (Zhang et al., 2020; Liu et al., 2021) and promoting the progression of papillary thyroid carcinoma (Yang et al., 2020) and esophageal squamous cell carcinoma (Zhang Y. et al., 2019). Here, IGF1 is linked to thyroid gland papillary carcinoma.