IGF1 and esophageal squamous cell carcinoma: Moreover, the lncRNA NR2F1-AS1 was reported to be associated with the progression of various types of tumor, for instance by activating the IGF-1/IGF-1R/ERK pathway to promote breast cancer angiogenesis, inducing breast cancer lung metastasis dormancy by regulating NR2F1 and deltaNp63 (Zhang et al., 2020; Liu et al., 2021) and promoting the progression of papillary thyroid carcinoma (Yang et al., 2020) and esophageal squamous cell carcinoma (Zhang Y. et al., 2019).