LDLR and familial hyperaldosteronism: On one hand, the leucine insertion L10 also designated p.Leu21dup or p.L15_L16insL is a common variation associated with lower levels of LDL-C in populations with normal to low LDL-C levels, but also in patients suffering from FH carrying the same p.(Cys681X) mutation in the LDL receptor (LDLr) gene (Abifadel et al., 2009).