Interestingly, 3 types of cancer, including colon adenocarcinoma (COAD), pheochromocytoma and paraganglioma (PCPG) and Rectum adenocarcinoma (READ), exhibited significantly lower SLC6A8 expression as compared to their respective normal tissues (Figure 1A). The gene discussed is SLC6A8; the disease is hereditary pheochromocytoma-paraganglioma.