Some of the inflammatory pathways and immune response signaling pathways were enriched in three MPN subtypes, such as chemokine signaling pathway, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, neutrophil extracellular trap formation, phagosome, as well as IL-17 signaling pathway (Figure 2), demonstrating that the inflammation and related immune response may participate in the pathogenesis of three MPN entities. This evidence concerns the gene IL17A and myeloproliferative neoplasm.