Overall, the four interferon-stimulated genes (OAS1, IFITM3, GBP1, and GBP2) exclusively upregulated in myelofibrosis might not only provide important novel clues to the MPN field but also offer special insights into the effects of IFN signaling on the pathogenesis of myelofibrosis. The gene discussed is IFITM3; the disease is myelofibrosis.