Overall, the four interferon-stimulated genes (OAS1, IFITM3, GBP1, and GBP2) exclusively upregulated in myelofibrosis might not only provide important novel clues to the MPN field but also offer special insights into the effects of IFN signaling on the pathogenesis of myelofibrosis. Here, IFITM3 is linked to myeloproliferative neoplasm.