ROC curves of CSMD2 expression in tumor and normal tissues showed that CSMD2 had high diagnostic efficiency in DLBC (AUC = 0.987, CI: 0.977–0.996), CHOL (AUC = 0.960, CI: 0.907–1.000), PAAD (AUC = 0.913, CI: 0.881–0.945), and THYM (AUC = 0.901, CI: 0.867–0.935), whereas, CSMD2 had low diagnostic efficiency in BLCA, CESC, GBM, LAML, PRAD, THCA, and UCEC, and had moderate diagnostic efficiency in other cancers (Figure 2). Here, CSMD2 is linked to neoplasm.