In addition, we also found that the CCPOC was related to weakened tumor immunogenicity and inflamed antitumor immunity, and the correlation analysis showed that CCPOC was negatively related to the ORR in pan-cancer (OC excluded), which indicated that the CCPOC-low group may be sensitive to anti-PD-1/PD-L1 therapy. Here, CD274 is linked to neoplasm.