The only covariates with SMDs above the threshold of 0.2 (for small differences) were age, obesity, and previous use of insulins, SGLT-2 inhibitors, DPP-IV inhibitors, and GLP-1 receptor agonists; with GLP-1 receptor agonists exhibiting by far the largest difference (SMD 0.865). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.