NBPF1 and inborn error of immunity: Meanwhile, GSEA analysis was carried out to confirm the putative signaling pathways of NBPF1 in the external (GEO) dataset, and the results suggested that genes relevant to NBPF1 were negatively associated with cytokine–cytokine receptor interactions, primary immunodeficiency, and the toll-like receptor signaling pathway (Supplementary Figure 12).