PubMed and Google scholar tools were used to retrieve relevant publications by using the following terms: Noonan syndrome, PTPN11, KRAS, SOS1, RAF1, NRAS, BRAF, MEK1, RIT1, SOS2, LZTR1, MRAS, CBL, RRAS, RRAS2, RASA2, SPRED1, growth, growth hormone, GH, GH treatment, puberty, scoliosis, cancer, tumor, brain tumor, MRI, Chiari malformation, dysembryoplastic, pilocytic, medulloblastoma, oligodendroglioma, glioneuronal, astrocytoma, glioma, ependymoma,pulmonary stenosis, and hypertrophic cardiopathy. The gene discussed is PTPN11; the disease is brain neoplasm.