KAT5 and posterior cortical atrophy: Coffey et al., using HTS and targeted compound synthesis, identified NU9056 (1,2-bis(4-pyridyl)-ethan; an isothiazole), a highly-selective and potent inhibitor against TIP60 catalytic activity, and showed that NU9056 treatment could inhibit cell growth and colony formation in several PCa cells including androgen sensitive LNCaP and insensitive PC-3 cells (152).