Several mechanisms have subsequently been proposed for the PCa preventive activity displayed by PEITC, including caspase-dependent apoptosis induction in TRMP-derived cells, through inhibition JAK-STAT3 signal-cascade activation in PCa cells, inhibition of IL6-induced AR transcriptional activity in LNCaP cells, by altering miRNA expression, reducing protein levels of MMP2 and MMP9 in PCa cells, and through inhibition of c-Myc expression and c-Myc regulated glycolysis in PCa cells (147–150). Here, STAT3 is linked to posterior cortical atrophy.