In the search for identifying specific and potent inhibitors of p300 catalytic activity for the purpose of inhibiting both androgen sensitive and castrate resistant PCa growth, Lasko and coworkers conducted virtual screening of approximately 800,000 compounds and identified a highly selective p300/CBP catalytic inhibitor, A-485, that was at least 1000-fold more potent than previously reported p300 inhibitor C646 and showed favorable ADME properties and PK profile (144). This evidence concerns the gene EP300 and posterior cortical atrophy.