Their work provided substantial evidence to show that under androgen-deprived conditions, the level of the AR coregulator p300 is increased, which can mediate transactivation of the AR by a cytokine, interleukin-6 (IL-6), that facilitate PCa progression via the stimulation of proliferation and angiogenesis and inhibition of apoptosis (46–48). This evidence concerns the gene IL6 and posterior cortical atrophy.