Deregulated actions of AR signaling has been implicated in the pathogenesis and progression of many AR-related disorders including Kennedy’s disease, androgen insensitivity syndrome (AIS), male infertility, prostatic hypertrophy, and multiple endocrine-related cancers such as prostate, breast, bladder, lung, liver, and kidney (3, 4, 6). This evidence concerns the gene AR and androgen insensitivity syndrome.