CRP and Insulin resistance: Several studies show an association of the serum soluble RANKL (sRANKL) level with Body Mass Index (BMI), lipids profile, Homeostatic Model Assessment- Insulin Resistance (HOMA-IR), diabetes, blood pressure, C-reactive protein (CRP) (19, 21–24), carotid intima-media thickness (cIMT) (25) and CV events (26, 27).