The most common exogenous estrogens contain those metabolized and excreted by living organisms into the environment, selective estrogen receptor modulators (SERMs) targeting the ER for the treatment of endocrine disorders (such as diethylstilbestrol and raloxifene), and environmental pollutants generated by industrial and agricultural activities (such as polycyclic aromatic hydrocarbons and phenolic compounds) (8, 9). Here, ESR1 is linked to endocrine system disorder.