This consistent increase in SOD, CAT, and GSH by notably STIG and STIG+DEX correlates well with their protective effects against asthma-induced dyspnea in Guinea pigs, suggesting that enhancement of antioxidant capacity by the treatment may have contributed to the ameliorative effect of STIG+DEX in the current model of steroid-resistant asthma which is desirable and crucial in managing airway inflammation in steroid asthma. Here, SOD1 is linked to asthma.