TANs impair antitumor immunity and accelerate tumor growth and metastasis through the production of growth factors, chemokines, and inflammatory factors such as matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), high mobility group box 1 (HMGB1), and interleukin (IL)-17 (Bald et al., 2014; Minder et al., 2015; Li et al., 2019; Shaul and Fridlender, 2019). The gene discussed is HMGB1; the disease is neoplasm.