SNAI1 and neoplasm: These chemotactic factors recruit neutrophils to tumor sites and generate reactive oxygen species through phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/zinc finger protein SNAI1 (Snail) signaling, inhibiting EMT and converting neutrophils to an antitumor phenotype (Liu et al., 2021a) (Figure 2A).