Additionally, in neutrophil-specific anterior gradient-2 (AGR2) knockout mice, a recent study reported that CRC cells aggressively attracted AGR2+ TANs, which enhanced CRC metastasis, through chemokine (C-X-C motif) ligand 2 (CXCL2) (Tian et al., 2022). The gene discussed is CXCL2; the disease is colorectal carcinoma.