Additionally, in neutrophil-specific anterior gradient-2 (AGR2) knockout mice, a recent study reported that CRC cells aggressively attracted AGR2+ TANs, which enhanced CRC metastasis, through chemokine (C-X-C motif) ligand 2 (CXCL2) (Tian et al., 2022). This evidence concerns the gene XCL2 and colorectal carcinoma.