For example, using a model PMN involving a hyaluronic acid (HA)-based gel loaded with CXCL12 (CLG), the tumors were revealed to induce PMNs in target organs, producing the tumor-derived factor CXCL12, which induces the recruitment of neutrophils and attracts CXCR4+ tumor cells both in vivo and in vitro (Ieranò et al., 2019). Here, CXCR4 is linked to neoplasm.