PDAC-related pathways were enriched in the high-m5C-score group, which included “pathways in cancer”, “pancreatic cancer”, and several signaling pathways (TGF-beta, MAPK, p53, hedgehog, ERBB and Wnt; Supplementary Table S9; Figures 5C,D). The gene discussed is TP53; the disease is familial pancreatic carcinoma.