All the statistically significant parameters (p < 0.05) were then selected to draw ROC curves, which showed that the m5C-score had the highest AUC at 1-, 3- and 5-year OS compared with either the m5C-score individual genes (Figures 4E–G), the m5C-methylation reader YBX1 or common PDAC serum tumor markers (Figures 4H–J). This evidence concerns the gene YBX1 and neoplasm.