For these studies, we found that the more differentiated human T-ALL cells were killed faster by treatment with HDAC or histone demethylase inhibitors if cultured in the adipocyte secretome, which suggest that adipocyte-induced changes to the epigenome of human T-ALL cells can be exploited to enhance the potency of epigenetic modifying drugs. This evidence concerns the gene HDAC9 and acute lymphoblastic leukemia.