Based on our RNA-sequencing analysis, which revealed substantial alterations in genes regulating the cell cycle and checkpoint responses to double-strand DNA breaks (ATM, ATR, CHEK1, and CHEK2) when human T-ALL cells were exposed to the adipocyte secretome, we next assessed cell cycle progression in leukemia cells cultured in unconditioned media, SCM, and ACM. The gene discussed is ATR; the disease is acute lymphoblastic leukemia.