Similar to the obesity-induced suppression of T-ALL pathogenesis in vivo, ACM was highly cytotoxic to human T-ALL cells over 3 days of culture (45%–84% cell death) and occurred independently of wild-type or mutant p53 expression (Table 2; Supplementary Figure S2A; Figures 1D,E). Here, TP53 is linked to obesity due to melanocortin 4 receptor deficiency.