RING1 and acute lymphoblastic leukemia: Furthermore, the gene encoding the polycomb protein EED, which is involved in maintaining the transcriptional repressive state of genes (Obier et al., 2015), was suppressed in all human T-ALL cell lines tested when cultured in ACM relative to the other conditions tested; whereas, RING1, which is also part of the polycomb complex (Stock et al., 2007), was upregulated when human T-ALL cells were exposed to the adipocyte secretome (Figures 2C–E).