ATM and leukemia: In support of the induction of DNA damage programs in human T-ALL cells cultured in ACM, we observed increased gene expression levels of ATM, which responds primarily to double-stranded breaks (DSBs), in leukemia cells exposed to the adipocyte secretome; whereas, this gene was downregulated in T-ALL cells cultured in SCM (with the exception of Loucy cells; Figures 2C–E).