NOTCH1 and acute lymphoblastic leukemia: For syngeneic experiments, lean and obese C57BL/6 mice were transplanted with hematopoietic stem and progenitor cells (c-kit+ cells) expressing activated NOTCH1, which is a potent driver of T-ALL development found to be mutated in 60% of childhood T-ALL cases (Lee et al., 2005; Garcia-Peydro et al., 2018).