A4GALT and bacterial urinary tract infection: Gb3-depleted cells (A4GALT gene knock-out) become insensitive to Shiga toxins;p phenotype individuals resistant to Shiga toxins toxicity; over 63, 000 cases (USA); huge economic losses during outbreaks11, 000, 000 cases/year in the USA, approximately 150, 000, 000 worldwide. Several factors are related with develop a UTI phenotype: dysfunctions of the urinary tract and/or genetic mechanisms involved in the innate immune response control220, 000, 000 cases and over 50, 000 deaths annually (in developing countries among children aged <5 years)