GCG and type 2 diabetes mellitus: Several N-acyl-phosphatidy lethanolamines and glucagon-like peptide-1 secreting engineered microbes including Lactobacillus gasseri and E. coli. Nissle 1917 have been used for T1DM and T2DM therapy, which can offer an enormous advantage in improving insulin resistance and glucose homeostasis (Chen et al., 2014; Duan et al., 2015).