GCG and rheumatoid arthritis: At 95 days of age, the primary metabolic pathways were ABC transporters, non-alcoholic fatty liver disease, rheumatoid arthritis, human papillomavirus infection, biotin metabolism, AMPK signaling pathway, lysine degradation, central carbon metabolism in cancer, and linoleic acid metabolism (Figure 10B), and those at 125 days of age were renal cell carcinoma, arginine and proline metabolism, and glucagon signaling pathway (Figure 10C).