IFNG and infection: Aside from the anti-microbial effect of IFN-γ the immunoregulatory functions may also play a role since elevated IFN-γ levels in the vaccinated groups after Bp K96243 challenge (day 79) may limit excessive neutrophil infiltration into the lungs during the acute stages of infection, with neutrophilia in the lungs being potentially indicative of poor survival outcome due to suboptimal Th1 mediated immune response (Nandi and Behar, 2011; Bearss et al., 2017; Kanno et al., 2019).