Overexpression of SIRT3 has been reported in several OSCC cell lines, while the administration of SIRT3 inhibitors such as sirtinol and nicotinamide enhanced the sensitivity of OSCC cells to radiation and cisplatin treatment via the accumulation of ROS to induce tumor cell apoptosis (Alhazzazi et al., 2011a). The gene discussed is SIRT3; the disease is neoplasm.