Interestingly, SIRT6 overexpression also promotes osteogenic differentiation and inhibits LPS-induced inflammatory response via suppressing NF-κB pathway in a periodontitis mode constructed by PDLSCs, which could be transcriptionally activated by Krüppel-like factor 5 (KLF5) (Li et al., 2022). This evidence concerns the gene SIRT6 and periodontitis.