SIRT3 and head and neck squamous cell carcinoma: It was reported that the survival and proliferation of human head and neck squamous cell carcinoma (HNSCC) cells were inhibited by the SIRT3 inhibitor LC-0296, and intracellular ROS and DNA cleavage were observed to be significantly upregulated in LC-0296-treated HNSCC cells (Alhazzazi et al., 2016).