For instance, sirtinol, the dual inhibitor of SIRT1 and SIRT2 that identified through phenotypic screening (Grozinger et al., 2001), has shown inhibitory effects on several tumor cell lines such as human breast cancer MCF-7 cells (Wang et al., 2012), lung cancer H1299 cells (Ota et al., 2006), human T cell leukaemia MT-2 cells (Kozako et al., 2012). The gene discussed is SIRT2; the disease is neoplasm.