The Akt/GSK-3β signaling pathway is known to be critically involved in various pathological processes of the heart (Liu et al., 2020), including myocardial fibrosis (Qin et al., 2021), myocardial hypertrophy (Dorn and Force, 2005), and ischemia-reperfusion injury (Mocanu and Yellon, 2007). The gene discussed is GSK3B; the disease is cardiac hypertrophy.