Matsumoto et al. (2020) demonstrated that TRPV4 in both macrophages and endothelial cells was involved in the regulation of AOM/DSS-induced colon carcinogenesis in mice. TRPV4 deficiency significantly reduced colitis-associated tumorigenesis and improved survival rate, compared with that in WT (Ou-Yang et al., 2018). The gene discussed is TRPV4; the disease is infectious otitis media.