We found that there is a strong association between IL6R rs4845625 and vulnerable carotid plaque in man (dominant model TT vs. CT + CC: adjusted OR 1.52, 95% CI 1.12–2.07, p = 0.007; codominant model TT vs. CC: adjusted OR 1.50, 95% CI 1.00–2.25, p = 0.048) but not in women (all p > 0.05), after adjusting for age, family history of stroke, hypertension, smoking status, and BMI (Table 5). The gene discussed is IL6R; the disease is Hypertension.