Meta-analyses including individual participant data from Mendelian randomization studies suggested a specific functional genetic variant Asp358Ala (rs2228145) in the IL6R had effects on biomarkers of inflammation and related pathways (soluble IL-6 and IL6R, C-reactive protein, fibrinogen, and others), and was associated with a reduced risk of coronary heart disease (Sarwar et al., 2012; Swerdlow et al., 2012). Here, CRP is linked to coronary artery disorder.