IL6 and endothelial dysfunction: As we known, persistent local and systemic inflammation has been implicated in all stages of atherogenesis, from endothelial dysfunction to onset of atherosclerotic plaque rupture and their thrombotic complications (Ross, 1999), while IL-6 signaling pathway is a master player closely associated with the pathogenesis of atherosclerotic disease (Scheller and Rose-John, 2012).