Chen et al. [30] found that GOLM1 is positively connected to invasive tumor-associated macrophages inhibited by PD-L1 and CD8+ T cells in colorectal cancer tissues, and zoledronic acid combined with anti-PD-L1 therapy reduces CD8+ T cell inhibition and pD-L1 + TAMs infiltration, resulting in inhibition of tumor growth in mice HCC model. This evidence concerns the gene CD274 and hepatocellular carcinoma.