Liu et al. [42] confirmed that methyltransferase-like 1 (METTL1) acts as a tumor suppressor in colon cancer by activating m7G-regulated let-7e miRNA/HMGA2 axis through quantitative PCR, Western blot, CCK-8 assay, transwell assay, and dual-luciferase reporter gene system. The gene discussed is HMGA2; the disease is colonic neoplasm.