APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; GCS: Glasgow Coma Scale; NT: native thiol; TT: total thiol; DB: disulphide bond; RT: reduced thiol; OT: oxidized thiol; TOR: thiol oxidation-reduction; COVID-19: Coronavirus disease 2019; ICU: intensive care unit; WBC: white blood cell; LDH: lactate dehydrogenase; CRP: C-reactive protein. The gene discussed is CRP; the disease is COVID-19.