These include the statuses of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), the local stage of the breast lesion, and paclitaxel/carboplatin-based chemotherapy for disseminated NPC. Compared to primary breast malignancy, metastases to the breasts are more likely to be superficial, less likely to be fixed to the underlying muscle or skin, and round and well marginated [8]. The gene discussed is ESR1; the disease is nasopharyngeal carcinoma.