Although infrequent, metastasis to the breast from NPC should be contemplated and ruled out by a thorough clinical examination and relevant radiological investigations, especially in cases of advanced disease. An unfortunate misdiagnosis as primary carcinoma breast could lead to unnecessary mastectomy or a hormone receptor status-driven chemotherapy while the primary disease (NPC) may progress unchecked. This evidence concerns the gene NR4A1 and nasopharyngeal carcinoma.