Guaita-Esteruelas et al. (2018) elucidated the role of FABP4 in the tumor microenvironment (TME) to promote carcinogenesis and the development of carcinoma. FABP4 has been proven to promote breast (Li et al., 2019), prostate (Liu and Godbout, 2020), ovarian (Nieman et al., 2011) cancers and other malignant tumors (Figure 2). Here, FABP4 is linked to cancer.