Furthermore, overexpression of FABP4 by transfection in prostate cancer cell lines induces apoptosis by decreasing transforming growth factor-alpha activity and upregulating the expression of TNF-α, indicating a possible contribution of FABP4 in tumor suppression (De Santis et al., 2004; Hammamieh et al., 2004). The gene discussed is FABP4; the disease is Familial prostate cancer.