Exalted circulating FABP4 content is strongly related to obesity, atherosclerosis, cardiovascular events, insulin resistance, hypertension and diabetes (Xu et al., 2006; Xu et al., 2007; Furuhashi et al., 2014; Hao et al., 2018a; Prentice et al., 2019; Lee et al., 2021a) (Figure 1). This evidence concerns the gene FABP4 and obesity due to melanocortin 4 receptor deficiency.