RUNX2 and myotonic dystrophy type 1: For example, the TFs: RUNX2, TSHZ3, and GLI-1 that bear 6 CUG/CAG repeats and were enriched for the upregulated genes, significantly regulate genes associated with extracellular matrix organization (RUNX2 and TSHZ3, FDR adjusted p-values: 5.7*10−6 and 0.0325, respectively) and collagen biosynthesis (GLI-1, FDR adjusted p-value = 2.7*10−18), pathways that were accordingly found to be upregulated in DM1 samples.