In the two gene sets of DEG-Megreen and DEG-Meturquoise, we listed ten hub genes that affect the pathogenesis of CRSwNP; our experiments proved that, in DEG-Megreen, FPR2, ITGAM, C3AR1, FCER1G, and CYBB are most significantly positively correlated with CRSwNP. The gene discussed is CYBB; the disease is chronic rhinosinusitis with nasal polyps.