IFN-γ released by CD8+ T cells downregulates the expression of two subunits of the glutamate-cysteine anti-transport system, SLC3A2, and SLC7A11, inhibits the uptake of cystine by tumor cells and promotes tumor cells lipid peroxidation and ferroptosis (Yamazaki et al., 2014; Wang et al., 2019). Here, CD8A is linked to neoplasm.