HMGB1 and cancer: This indicates that cancer cells undergoing ferroptosis release HMGB1, an important protein necessary to make cancer cells immunogenic, and DAMPs, an endogenous molecule released from injured or stressed cells (Tang et al., 2012; Yu et al., 2015; Wen et al., 2019; Zindel and Kubes, 2020; Chen et al., 2021).