PRR11 and cancer: Studies have shown that proline rich 11 (PRR11) contains a bivalent nuclear localization signal, two proline-rich regions, and a zinc finger domain, which is a well-known domain that can bind double-stranded DNA, modulate gene transcription (Zhou et al., 2019), and participate in cell signal transduction leading to a series of cancer-related events (Qiao et al., 2019).