From the result of the overlap genes between TCGA-4 Cs and RNA-seq, four genes were found to be influenced by PRR11 downregulation, including PTTG1, BRCA2, ATAD2, and BRIP1. PTTG1 has been reported as one of the cell cycle–related genes (Horning et al., 2018; Deng et al., 2021) and to be upregulated in breast, pituitary, ovarian, and uterine cancers (Vlotides et al., 2007). The gene discussed is BRCA2; the disease is uterine cancer.