Recent evidence suggested that its upregulation may promote pan-cancer development by influencing cyclin genes and p38 MAPK (Lin et al., 2020), Wnt/β-catenin (Qiao et al., 2019; Zhou et al., 2019), PI3K/AKT/β-catenin (Zhu et al., 2018), and Akt/mTOR autophagy (Zhang et al., 2018) signaling pathways. Here, PCNA is linked to cancer.