AKT1 and esophageal cancer: Although it was reported that PRR11 could mediate the Akt/mTOR signaling pathway in non-small-cell lung cancer (Zhang et al., 2018), p38 MAPK signaling in pancreatic cancer cells (Lin et al., 2020), as well as Wnt/β-catenin signal transduction in both esophageal cancer (Zhou et al., 2019) and hepatic carcinoma (Qiao et al., 2019) to participate in cancer development, all of them do not significantly enrich in our GO and KEGG results of both TCGA and RNA-seq.