Utilizing a cell-impermeable small molecule Hsp90 inhibitor (DMAG-N-oxide), eHsp90 inhibition was found to decrease tumor cell migration and ECM reorganization in cell models and decreased melanoma lung colonization in a mouse model, while not affecting intracellular Hsp90 function (Tsutsumi et al., 2008). The gene discussed is HSP90AA1; the disease is melanoma.