In prostate cancer, extracellular vesicles (EVs) enriched with Hsp90 and other HSPs promoted EMT in normal epithelial cells, and the co-chaperone Cdc37 played a crucial role in stress-induced release of vesicles and eHsp90 to promote tumorigenesis (Eguchi et al., 2020). Here, HSP90AA1 is linked to Familial prostate cancer.