Tumor cells actively release Hsp90 (eHsp90) into the extracellular space where it participates in the pathological multistep process of metastasis by promoting tumor cell invasion (reviewed in (Li et al., 2012; Li et al., 2013; Wong and Jay, 2016; Poggio et al., 2021)). The gene discussed is HSP90AA1; the disease is neoplasm.