Desmedt et al. studied immune gene signatures for more than 2000 breast cancers and associated the different subtypes with different biological processes (tumor invasion/metastasis, immune response, angiogenesis, evasion of apoptosis, growth and proliferation, and ER and HER2 signaling), and each of these with a prognosis value (Table 1). The gene discussed is ERBB2; the disease is breast cancer.