As shown in Figure 4F, the 17 DMs-NIHL were significantly enriched in 12 pathways including retrograde endocannabinoid signaling, pentose and glucuronate interconversions, sphingolipid signaling pathway, choline metabolism in cancer, vitamin digestion and absorption, aldosterone synthesis and secretion, Fc gamma R-mediated phagocytosis, steroid biosynthesis, phospholipase D signaling pathway, apelin signaling pathway, central carbon metabolism in cancer, and purine metabolism. This evidence concerns the gene APLN and cancer.