Numerous studies have shown that the growth inhibitory effect of curcumin on various tumor cells is mediated through actions on numerous molecules in the signaling pathway, including p53, NF-κB, mitogen-activated protein kinases (MAPK), Akt/mammalian target of rapamycin (mTOR), Notch-1, nuclear factor erythroid 2-related factor 2 (Nrf2), Wnt/β-catenin, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and AMP-activated protein kinase (AMPK) [11]. This evidence concerns the gene NFE2L2 and neoplasm.