TF and Hepatic fibrosis: Yu et al. showed that high-iron diet can lead to ferroptosis in hepatocytes, eventually leading to liver fibrosis and impaired function; CCl4, a classical hepatotoxic chemical, can also cause liver damage by ferroptosis; the levels of serum transferrin and liver transferrin in clinical patients with liver cirrhosis are significantly reduced, and the levels of liver iron and lipid peroxidation are also significantly increased [46].