In this study, we demonstrated that QCWZD reduces the levels of proinflammatory factors, such as IL-6 and TNF-α, secreted by M1 macrophages both in vivo and in vitro, thereby alleviating DSS-induced colitis in mice, demonstrating the protective effect of QCWZD in the treatment of IBD. The gene discussed is IL6; the disease is colitis.