Similarly, in a choline-deficient amino acid diet-induced non-alcoholic steatohepatitis (NASH) model, loss of LOXL1 in the liver ameliorated systemic lipid metabolism abnormalities, including normalizing weight loss, increasing serum triacylglycerol (TAG) levels by facilitating the transport of TAG from the liver to the bloodstream, and increasing fat weight (Dhariwal et al., 2017). This evidence concerns the gene LOXL1 and metabolic dysfunction-associated steatohepatitis.